Based on a study from researchers at St. Jude Children’s Research Hospital the vaccinated are more susceptible to COVID variants. Substack author eugyppius shared their results:
Over 4.2 billion people across the earth have received at least one dose of vaccine against SARS-2. The majority of these vaccines have elicited antibodies only against an early form of the spike protein that is no longer in circulation.
This would seem to be one reason why many western countries with high vaccination rates appear to have locked themselves into an indefinite phase of heightened SARS-2 transmission. In the United Kingdom, 96% of adults have antibodies to the spike protein – most of these first acquired by vaccination. Shortly after they concluded their vaccination campaign, cases skyrocketed, and they have remained high ever since.
The article goes on to state the following:
In this case, it seems possible that many vaccinated people will be stuck with permanently suboptimal immune responses. If Omicron is indeed circulating primarily among the vaccinated, as some data suggests, this would seem to be one possibly reason why. These concerns are particularly acute in the case of children, who may well be exposed to the risk of very serious illness in the future, if vaccination permanently misdirects their immune system.
What does this mean?
Three things: 1) OD stands for “optical density.” The higher the OD, the higher the antibody levels. 2) The blue “none” dots represent control mice that did not receive either the first or the second immunisations. 3) OC43 and HKU1 are betacoronaviruses and most closely related to SARS-2; 229E and NL63 are alphacoronaviruses and more distantly related to SARS-2.
In A, you see that all mice produced plenty of antibodies to the full-length spike protein of SARS-2, regardless of prior exposure to common coronavirus spike proteins In B, you see that antibodies to the crucial receptor binding domain (RBD) of SARS-2 are significantly inhibited by prior exposure to common human coronaviruses, especially by prior exposure to HKU1 and NL63. In C, we are dealing with neutralisation assays, and the y-axis is “percent inhibition” – how much the anti-spike antibodies are actually interfering with the spike protein. Here we see that whatever antibodies are produced by the common coronavirus-immunised mice in response to SARS-2 spike exposure, these do a very poor job of neutralising the SARS-2 spike protein.
Your immune response based on immunization creates an inadequate or incorrect response to exposure. This makes even weaker strains more dangerous to the people who got the vaccine.
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